We have seen Dollies and trout charge across a stream to eat this fly!
We suggest fishing Glo Bugs on a nymph-style leader set up. The goal is to get the fly near the bottom and let it drift naturally. Start with a Rio 9 foot Trout Leader in 2X (10lb) or 3X (8lb), tie on the Glo Bug and add split shot about 18" up from the fly. If you aren't sure what size split shot to use, start with BB.
Then add a strike indicator. Thing-A-Ma-Bobbers in 3/4" size are our favorites. Place the indicator approximately 1.5 - 2 times the water depth away from the fly. For instance, if the water is 3 feet deep, place the indicator 4.5-6 feet from the fly. Adjust the indicator as needed to allow the fly to sink near the bottom while simultaneously allowing you to see strikes as soon as they happen.